[A case report of anorectal malignant melanoma showing a complete response after DTIC/ACNU/VCR therapy].

Abstract

We report herein the case of a 64-year-old male who presented with hematochezia. The patient was diagnosed with malignant melanoma of the anorectum using colonoscopy. Preoperative studies revealed no distant metastases, and he underwent Miles operation. Pathological exams revealed that the tumor had invaded the submucosa with lymphatic and venous invasion. Cancer cells were found in regional lymph nodes. Post-operative CT scan demonstrated multiple metastases in the liver, and he received two courses of combined chemotherapy, DAV regimen (dacarbazine: DTIC 100 mg iv days 1-5, nimustine hydrochloride: ACNU 100 mg iv day 1, vincristine sulfate: VCR 1 mg iv day 1), leading to a complete response. However, malignant melanoma cells were found in hernia contents at the operation for left inguinal hernia, which led to a diagnosis of recurrent malignant melanoma. The patient has subsequently been well without any sign of recurrence including liver metastases. To our knowledge, this is the first report of a complete response in a patient with multiple liver metastases of anorectal malignant melanoma after DAV regimen.

• Authors: Shin Sasaki, Tetsu Kojima, Akio Hidemura, Kazuhito Hatanaka, Toshimasa Uekusa, Masahiro Ishimaru
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 10 Pg. 1999-2002 (Oct 2010) ISSN: 0385-0684 [Print] Japan
• PMID: 20948273 (Publication Type: Case Reports, Journal Article)

Chemical References

• Nimustine
• Vincristine
• Dacarbazine

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Anus Neoplasms (diagnostic imaging, drug therapy, pathology, surgery)
• Combined Modality Therapy
• Dacarbazine (administration & dosage, therapeutic use)
• Humans
• Liver Neoplasms (diagnostic imaging, drug therapy, secondary)
• Male
• Melanoma (diagnostic imaging, drug therapy, pathology, surgery)
• Middle Aged
• Nimustine (administration & dosage, therapeutic use)
• Remission Induction
• Tomography, X-Ray Computed
• Vincristine (administration & dosage, therapeutic use)