Fragrance mix II in the baseline series contributes significantly to detection of fragrance allergy.

Abstract

BACKGROUND:

Fragrance mix II (FM II) is a relatively new screening marker for fragrance contact allergy. It was introduced in the patch test baseline series in Denmark in 2005 and contains six different fragrance chemicals commonly present in cosmetic products and which are known allergens.

AIM:

To investigate the diagnostic contribution of including FM II in the baseline series by comparing it with other screening markers of fragrance allergy: fragrance mix I (FM I), Myroxylon pereirae and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC).

METHOD:

Retrospective study of 12 302 patients consecutively patch tested with FM II by members of the Danish Contact Dermatitis Group 2005-2008.

RESULTS:

FM II gave a positive patch test in 553 patients (4.5%), and in 72.2% of these patients the reaction was judged to be clinically relevant. FM II ranked second in detecting fragrance allergy, after FM I. If FM II had not been included as a screening marker in the baseline series, 15.6% (n = 202) of individuals with fragrance allergy would not have been identified by the other fragrance screening markers (FM I, M. pereirae or HICC).

CONCLUSION:

FM II contributes substantially to detecting fragrance allergy. It ranked second among the fragrance screening markers tested in the baseline series and detects individuals with an allergy who otherwise would not have been identified.

• Authors: Maria V Heisterberg, Klaus E Andersen, Christian Avnstorp, Berit Kristensen, Ove Kristensen, Knud Kaaber, Grete Laurberg, Torkil Menné, Niels Henrik Nielsen, Mette Sommerlund, Jens Thormann, Niels K Veien, Susanne Vissing, Jeanne D Johansen
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 63 Issue 5 Pg. 270-6 (Nov 2010) ISSN: 1600-0536 [Electronic] England
• PMID: 20946455 (Publication Type: Comparative Study, Journal Article, Multicenter Study)
• Copyright: © 2010 John Wiley & Sons A/S.

Chemical References

• Aldehydes
• Allergens
• Cosmetics
• Cyclohexenes
• hydroxyisohexyl 3-cyclohexene carboxaldehyde

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Aldehydes (adverse effects)
• Allergens (adverse effects)
• Chi-Square Distribution
• Child
• Child, Preschool
• Cosmetics (adverse effects)
• Cyclohexenes (adverse effects)
• Denmark
• Dermatitis, Allergic Contact (diagnosis)
• Female
• Humans
• Infant
• Male
• Middle Aged
• Myroxylon (adverse effects)
• Patch Tests (methods, statistics & numerical data)
• Retrospective Studies
• Young Adult