Temozolomide for adult brain stem glioblastoma: case report of a long-term survivor.

Abstract

Brain stem gliomas are rare intracranial tumors, especially in adults. Malignant or high-grade brain stem gliomas are usually associated with a very poor prognosis. This case report documents an adolescent harboring brain stem glioblastoma who had complete radiological response to temozolomide after partial tumor resection and survived for more than 3 years. Radiological and pathological findings are described. To the best of our knowledge, no similar cases have been reported in the literature.

• Authors: Chao Zhang, Yu Yao, Yin Wang, Zheng Chen, Jinsong Wu, Ying Mao, Liangfu Zhou
• Journal: The International journal of neuroscience (Int J Neurosci) Vol. 120 Issue 12 Pg. 787-91 (Dec 2010) ISSN: 1563-5279 [Electronic] England
• PMID: 20946086 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Alkylating
• Dacarbazine
• Temozolomide

Topics

• Antineoplastic Agents, Alkylating (administration & dosage)
• Brain Stem Neoplasms (drug therapy, mortality, surgery)
• Dacarbazine (administration & dosage, analogs & derivatives)
• Fatal Outcome
• Glioblastoma (drug therapy, mortality, surgery)
• Humans
• Male
• Survival Rate (trends)
• Temozolomide
• Treatment Outcome
• Young Adult