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Diagnosis of bromethalin toxicosis in the dog.

Abstract
Dogs given a single oral dose of bromethalin at 6.25 mg/kg developed a toxic syndrome characterized by hyperexcitability, tremors, seizures, depression, and death within 15-63 hours after bromethalin administration. Gross lesions included mild cerebral edema (2/5) and mild pulmonary congestion (2/5). Histologic lesions included diffuse white matter spongiosis (5/5), mild microgliosis (3/5), optic nerve vacuolization (3/5), mild thickening of Bowman's capsule (2/5), and occasional splenic megakaryocytes (2/5). Ultramicroscopic examination of midbrain stem revealed occasional swollen axons, intramyelinic vacuolization, and myelin splitting at the intraperiod line. Bromethalin was detected in kidney, liver, fat, and brain tissues, using gas chromatography with electron capture detection. Photodegradation of extracted bromethalin may limit accurate quantification of tissue residues.
AuthorsD C Dorman, J Simon, K A Harlin, W B Buck
JournalJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc (J Vet Diagn Invest) Vol. 2 Issue 2 Pg. 123-8 (Apr 1990) ISSN: 1040-6387 [Print] United States
PMID2094433 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aniline Compounds
  • Rodenticides
  • bromethalin
Topics
  • Adipose Tissue (chemistry)
  • Aniline Compounds (analysis, poisoning)
  • Animals
  • Axons (pathology)
  • Brain (pathology)
  • Brain Chemistry
  • Dog Diseases (chemically induced, diagnosis, pathology)
  • Dogs
  • Kidney (chemistry)
  • Liver (chemistry)
  • Male
  • Molecular Structure
  • Optic Nerve (pathology)
  • Poisoning (diagnosis, pathology, veterinary)
  • Rodenticides (analysis, poisoning)
  • Syndrome

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