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Fatigue and cognition in patients with relapsing multiple sclerosis treated with interferon β.

AbstractINTRODUCTION:
Fatigue and cognitive deficits are common symptoms affecting patients with multiple sclerosis.
METHODS:
The effects of interferon beta on fatigue and cognitive deficits were assessed in 50 patients with relapsing multiple sclerosis (recruited at a single center). The pre-treatment assessments were performed on visits 1 and 2 (Months 0 and 3). Patients started treatment with subcutaneous interferon beta-1a or beta-1b, or intramuscular interferon beta-1a at Month 3, with reassessment at visits 3 and 4 (6 and 12 months, respectively). Co-primary endpoints were change in fatigue (Modified Fatigue Impact Scale) and change in cognition (Brief Repeatable Battery of Neuropsychological Tests) from pre-treatment to visits 3 and 4. Follow-up data were obtained for 40 patients.
RESULTS:
The pre-treatment demographic and disease characteristics did not differ between groups. Improvements in fatigue levels were reported for patients receiving subcutaneous interferon beta-1a versus patients in the intramuscular interferon beta-1a group (p = .04) and in the interferon beta-1b group (p = .09). Improvements were also reported in five out of 17 cognitive indices for all the treatment groups.
CONCLUSION:
The data suggest that interferon beta may reduce fatigue and cognitive deficits in patients with relapsing multiple sclerosis. Larger, randomized, and controlled studies are required to confirm our findings.
AuthorsMaria Melanson, Amy Grossberndt, Meghann Klowak, Christine Leong, Emma E Frost, Michael Prout, Josee-Anne Le Dorze, Colin Gramlich, Malcom Doupe, Lisa Wong, Farid Esfahani, Andrew Gomori, Michael Namaka
JournalThe International journal of neuroscience (Int J Neurosci) Vol. 120 Issue 10 Pg. 631-40 (Oct 2010) ISSN: 1563-5279 [Electronic] England
PMID20942577 (Publication Type: Clinical Trial, Phase IV, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon beta-1b
  • Interferon-beta
  • Interferon beta-1a
Topics
  • Adolescent
  • Adult
  • Aged
  • Cognition Disorders (drug therapy, etiology)
  • Disease Progression
  • Fatigue (drug therapy, etiology)
  • Female
  • Humans
  • Injections, Intramuscular
  • Injections, Subcutaneous
  • Interferon beta-1a
  • Interferon beta-1b
  • Interferon-beta (administration & dosage)
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting (complications, drug therapy)
  • Pilot Projects
  • Prospective Studies
  • Young Adult

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