[Coumarin-induced necrosis--a rare complication of oral anticoagulant therapy].

Coumarin-induced skin necrosis represents a clinical entity that occurs very rarely, with an approximate incidence of 0.01-0.1% at patients following oral anticoagulant therapy. Most of the cases become clinical manifest between the 3rd and 6th of anticoagulant treatment (there were reports of late onset of skin necrosis after 15 years of anticoagulant therapy) and the most involved areas include breast, buttocks and thighs microcirculation-rich areas. Early symptoms include paresthesia and sensation of tension associated with an erythematous flush in the affected area. Lesions are well demarcated, painful, initially erythematous or hemorrhagic, with the onset of skin necrosis in the end stage. Early lesions can be reversible with the discontinuation of anticoagulant therapy, but skin necrosis can reoccur even without any other coumarin based treatment. We report the case of a 55-year-old female who presented with coumarin-induced skin necrosis affecting the right breast and the right deltoid area.
AuthorsF Graur, A Szasz, H Neagos, A Coţe, G Thdorică, L Furcea, A Mureşan, M Acalovschi, L Petrov, C Iancu, L Vlad
JournalChirurgia (Bucharest, Romania : 1990) (Chirurgia (Bucur)) 2010 Jul-Aug Vol. 105 Issue 4 Pg. 559-62 ISSN: 1221-9118 [Print] Romania
Vernacular TitleNecroza cumarinică--complicaţie rară a terapiei anticoagulante orale.
PMID20941983 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Anticoagulants
  • Coumarins
  • coumarin
  • Anticoagulants (administration & dosage, adverse effects)
  • Breast (pathology, surgery)
  • Coumarins (administration & dosage, adverse effects)
  • Female
  • Femoral Vein
  • Humans
  • Middle Aged
  • Necrosis
  • Shoulder (pathology, surgery)
  • Skin Diseases (chemically induced, pathology, surgery)
  • Treatment Outcome
  • Venous Thrombosis (drug therapy)

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