CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses.

Abstract

The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8(+) and CD4(+) T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8(+) gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4(+) T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.

• Authors: Patrícia C C Neves, Richard A Rudersdorf, Ricardo Galler, Myrna C Bonaldo, Marlon Gilsepp Veloso de Santana, Philip A Mudd, Maurício A Martins, Eva G Rakasz, Nancy A Wilson, David I Watkins
• Journal: Vaccine (Vaccine) Vol. 28 Issue 51 Pg. 8183-8 (Nov 29 2010) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 20939995 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Antigens, Viral
• Receptors, Antigen, T-Cell, gamma-delta
• Yellow Fever Vaccine
• Interferon-gamma

Topics

• Animals
• Antigens, Viral (immunology)
• CD4-Positive T-Lymphocytes (immunology)
• CD8-Positive T-Lymphocytes (chemistry, immunology)
• Interferon-gamma (metabolism)
• Macaca mulatta
• Receptors, Antigen, T-Cell, gamma-delta (analysis)
• T-Lymphocyte Subsets (chemistry, immunology)
• Yellow Fever Vaccine (administration & dosage, immunology)