Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells.

Abstract

Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D(2) (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation. Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.

• Authors: Yeon Hee Choi, Dae Seok Yoo, Mi-Ran Cha, Chun Whan Choi, Young Sup Kim, Sang-Un Choi, Kang Ro Lee, Shi Yong Ryu
• Journal: Journal of natural products (J Nat Prod) Vol. 73 Issue 11 Pg. 1863-7 (Nov 29 2010) ISSN: 1520-6025 [Electronic] United States
• PMID: 20939516 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Saponins
• Triterpenes
• deapio-platycodin D2
• deapio-platyconic acid B lactone
• platyconic acid B lactone

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Molecular Structure
• Plant Roots (chemistry)
• Platycodon (chemistry)
• Saponins (chemistry, isolation & purification, pharmacology)
• Triterpenes (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured