Adjuvant internal hepatic radiotherapy using colloidal 32P chromic phosphate in colorectal cancer.

Abstract

The purpose of the study is to investigate the value of adjuvant radiotherapy given in the form of colloidal chromic phosphate 32P suspension administered via portal vein, in preventing the growth of occult metastases in the liver. Twenty two patients (10 patients of treated group with 12 controls) were followed 12 months after operation. There was no significant change in the CBC and liver functions after administration of 32P labeled colloidal chromic phosphate. Although local recurrence rates were very similar in both groups of colorectal cancer (3/12 in the control group and 4/10 in the treated group), liver metastasis rates were quite different: 4/12 in the control group and none (0/10) in the treated group. In conclusion, 32P labeled colloidal chromic phosphate is expected to prevent liver metastases of completely resected colorectal cancer.

• Authors: J Y Kim, H S Bom, Y J Kim, W Choi
• Journal: Radiation medicine (Radiat Med) 1990 Nov-Dec Vol. 8 Issue 6 Pg. 246-9 ISSN: 0288-2043 [Print] Japan
• PMID: 2093946 (Publication Type: Journal Article)

Chemical References

• Chromium Compounds
• Phosphates
• Phosphorus Radioisotopes
• Chromium
• chromic phosphate

Topics

• Chromium (administration & dosage, adverse effects, therapeutic use)
• Chromium Compounds
• Colorectal Neoplasms (pathology, surgery)
• Combined Modality Therapy
• Female
• Humans
• Injections, Intravenous
• Liver Neoplasms (prevention & control, secondary)
• Male
• Middle Aged
• Phosphates (administration & dosage, adverse effects, therapeutic use)
• Phosphorus Radioisotopes (administration & dosage, adverse effects, therapeutic use)
• Portal Vein