AV119, a natural sugar from avocado gratissima, modulates the LPS-induced proinflammatory response in human keratinocytes.

Abstract

Keratinocytes play an active role in innate immune responses by secreting a variety of cytokines and chemokines. The release of critical proinflammatory cytokines, which are necessary to activate the immune response, is induced by the stimulation of Toll-like receptors (TLRs) by molecules present on pathogenic micro-organisms such as lipopolysaccharide (LPS). AV119, a patented blend of avocado sugars, induced the aggregation of Malassezia furfur, a dimorphic, lipid-dependent yeast that is part of the normal human cutaneous commensal flora and inhibited its penetration into the keratinocytes. In the present study, the anti-inflammatory effects of AV119 were investigated in LPS-induced inflammation of human keratinocytes. In particular, we analysed the modulation of the LPS-induced expression of proinflammatory cytokines and heat shock protein 70 (HSP70) by AV119 and the involvement of TLR-4. Our data show that AV119 is able to modulate significantly the proinflammatory response in human keratinocytes, blocking the NF-kB activation in human keratinocytes.

• Authors: Giovanna Donnarumma, Iole Paoletti, Elisabetta Buommino, Alessandra Fusco, Caroline Baudouin, Philippe Msika, Maria Antonietta Tufano, Adone Baroni
• Journal: Inflammation (Inflammation) Vol. 34 Issue 6 Pg. 568-75 (Dec 2011) ISSN: 1573-2576 [Electronic] United States
• PMID: 20936426 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• AV119
• Carbohydrates
• Cytokines
• Heat-Shock Proteins
• Lipopolysaccharides
• NF-kappa B
• Sugars
• Toll-Like Receptor 4

Topics

• Carbohydrates (immunology)
• Cytokines (analysis)
• Heat-Shock Proteins (analysis)
• Humans
• Immunity, Innate (drug effects)
• Inflammation (drug therapy)
• Keratinocytes (drug effects, immunology, pathology)
• Lipopolysaccharides (pharmacology)
• NF-kappa B (immunology)
• Persea (chemistry, immunology)
• Sugars
• Toll-Like Receptor 4 (immunology)