Abstract | OBJECTIVES: The association between tobacco smoke exposure and critical illness is not well studied, largely because obtaining an accurate smoking history from critically ill patients is difficult. Biomarkers can provide quantitative data on active and secondhand cigarette smoke exposure. We sought to compare cigarette smoke exposure as measured by biomarkers to exposure by self-report in a cohort of critically ill patients and to determine how well biomarkers of cigarette smoke exposure correlate with each other in this population. DESIGN, SETTING, AND PATIENTS: MEASUREMENTS AND MAIN RESULTS: By smoking history, 29 subjects were identified as smokers, 28 were identified as nonsmokers, and 3 were identified as unknown. The combination of serum cotinine and urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol identified 27 of the 28 nonsmokers by history either as active smokers (n = 6, 21%) or as exposed to secondhand smoke (n = 21, 75%). All biomarker levels were strongly correlated with each other (r = .69-.95, p < .0001). CONCLUSIONS:
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Authors | S Jean Hsieh, Lorraine B Ware, Mark D Eisner, Lisa Yu, Peyton Jacob 3rd, Christopher Havel, Maciej L Goniewicz, Michael A Matthay, Neal L Benowitz, Carolyn S Calfee |
Journal | Critical care medicine
(Crit Care Med)
Vol. 39
Issue 1
Pg. 40-5
(Jan 2011)
ISSN: 1530-0293 [Electronic] United States |
PMID | 20935560
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Nitrosamines
- Pyridines
- Tobacco Smoke Pollution
- hydroxycotinine
- 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
- Cotinine
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Topics |
- Academic Medical Centers
- Adult
- Aged
- Biomarkers
(blood)
- Cohort Studies
- Cotinine
(analogs & derivatives, analysis)
- Critical Illness
- Female
- Humans
- Male
- Middle Aged
- Nitrosamines
(analysis)
- Prevalence
- Pyridines
(analysis)
- Reference Values
- Risk Assessment
- Sensitivity and Specificity
- Smoking
(adverse effects, epidemiology)
- Statistics, Nonparametric
- Tennessee
- Tobacco Smoke Pollution
(statistics & numerical data)
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