PET imaging of brain cancer with positron emitter-labeled liposomes.
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| Abstract |
Since nanocarriers such as liposomes are known to accumulate in tumors of tumor-bearing animals, and those that have entrapped a positron emitter can be used to image a tumor by PET, we applied (18)F-labeled 100-nm-sized liposomes for the imaging of brain tumors. Polyethylene glycol (PEG)-modified liposomes, which are known to accumulate in tumors by passive targeting and those modified with Ala-Pro-Arg-Pro-Gly, which are known to home into angiogenic sites were used. Those liposomes labeled with DiI fluorescence accumulated in a glioma implanted in a rat brain 1h after the injection, although they did not accumulate in the normal brain tissues due to the protection afforded by the blood-brain barrier. Preformed liposomes were easily labeled with 1-[(18)F]fluoro-3,6-dioxatetracosane, and enabled the imaging of gliomas by PET with higher contrast than that obtained with [(18)F]deoxyfluoroglucose. In addition, the smallest tumor among those tested, having a diameter of 1mm was successfully imaged by the liposomal (18)F. Therefore, nanocarrier-based imaging of brain tumors is promising for the diagnosis of brain cancer and possible drug delivery-based therapy.
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| Authors | Naoto Oku, Mina Yamashita, Yurie Katayama, Takeo Urakami, Kentaro Hatanaka, Kosuke Shimizu, Tomohiro Asai, Hideo Tsukada, Shuji Akai, Hiroaki Kanazawa |
| Journal | International journal of pharmaceutics (Int J Pharm) Vol. 403 Issue 1-2 Pg. 170-7 (Jan 17 2011) ISSN: 1873-3476 [Electronic] Netherlands |
| PMID | 20934495 (Publication Type: Journal Article) |
| Copyright | Copyright © 2010 Elsevier B.V. All rights reserved. |
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