Objective and longitudinal assessment of dermatitis after postoperative accelerated partial breast irradiation using high-dose-rate interstitial brachytherapy in patients with breast cancer treated with breast conserving therapy: reduction of moisture deterioration by APBI.

Abstract

PURPOSE:

To objectively evaluate the radiation dermatitis caused by accelerated partial breast irradiation (APBI) using high-dose-rate interstitial brachytherapy.

PATIENTS AND METHODS:

The skin color and moisture changes were examined using a newly installed spectrophotometer and corneometer in 22 patients who had undergone APBI using open cavity implant high-dose-rate interstitial brachytherapy (36 Gy in six fractions) and compared with the corresponding values for 44 patients in an external beam radiotherapy (EBRT) control group (50-60 Gy in 25-30 fractions within 5-6 weeks) after breast conserving surgery.

RESULTS:

All values changed significantly as a result of APBI. The extent of elevation in a∗ (reddish) and reduction in L∗ (black) values caused by APBI were similar to those for EBRT, with slightly delayed recovery for 6-12 months after treatment owing to the surgical procedure. In contrast, only APBI caused a change in the b∗ values, and EBRT did not, demonstrating that the reduction in b∗ values (yellowish) depends largely on the surgical procedure. The changes in moisture were less severe after APBI than after EBRT, and the recovery was more rapid. The toxicity assessment using the Common Toxicity Criteria, version 3, showed that all dermatitis caused by APBI was Grade 2 or less.

CONCLUSION:

An objective analysis can quantify the effects of APBI procedures on color and moisture cosmesis. The radiation dermatitis caused by APBI using the present schedule showed an equivalent effect on skin color and a less severe effect on moisture than the effects caused by standard EBRT.

• Authors: Eiichi Tanaka, Hideya Yamazaki, Ken Yoshida, Tadashi Takenaka, Norikazu Masuda, Tadayuki Kotsuma, Yasuo Yoshioka, Takehiro Inoue
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 81 Issue 4 Pg. 1098-104 (Nov 15 2011) ISSN: 1879-355X [Electronic] United States
• PMID: 20932653 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Body Water (radiation effects)
• Brachytherapy (adverse effects, methods)
• Breast Neoplasms (pathology, radiotherapy, surgery)
• Combined Modality Therapy
• Dehydration (diagnosis, etiology, pathology)
• Dose Fractionation, Radiation
• Female
• Humans
• Longitudinal Studies
• Mastectomy, Segmental (adverse effects, methods)
• Middle Aged
• Pigmentation Disorders (etiology, pathology)
• Radiodermatitis (etiology, pathology)
• Skin Pigmentation (radiation effects)