[Comparison between carboplatin and cisplatin plus etoposide and carboplatin plus etoposide in the treatment of small cell lung cancer.].

Abstract

BACKGROUND:

To evaluate the effect and toxicity of combination chemotherapy with carboplatin and cisplatin plus etoposide (CPE regimen) and carboplatin plus etoposide (CE regimen) in the treatment of small cell lung cancer (SCLC) .

METHODS:

Thirty-two patients with SCLC were treated with CPE and CE regimens , and each regimen had 16 cases respectively. There were 10 retreated cases in CPE group and 7 retreated cases in CE group.

RESULTS:

The total response rate (CR + PR) was 81. 3 %(13/ 16) in CPE group , and 87. 5 %(14/ 16) in CE group ( P > 0. 05) respectively. The response rate of the retreated cases in CPE group was 60 %(6/ 10) , and 42. 9 %(3/ 7) in CE group ( P < 0. 05) . The bone marrow suppression rate was 71. 9 % in CPE group and 93. 8 % in CE group ( P < 0. 05) . There were no significant differences between other toxicity in both groups ( P > 0. 05) .

CONCLUSIONS:

The therapeutic effect of CPE regimen in SCLC is similar to that of CE regimen , but the bone marrow suppression rate of CPE regimen is less severe than that of CE regimen. The therapeutic effect of CPE regimen is better than that of CE regimen for the retreated cases.

• Authors: L Ren, M Hou, C Yi, D Luo, M Qiu, M Xie, Z Mei
• Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (Zhongguo Fei Ai Za Zhi) Vol. 2 Issue 2 Pg. 87-9 (Dec 25 1999) ISSN: 1009-3419 [Print] China
• PMID: 20929637 (Publication Type: English Abstract, Journal Article)