Alpha-adducin Gly460Trp polymorphism and hypertension risk: a meta-analysis of 22 studies including 14303 cases and 15961 controls.

Abstract

BACKGROUND:

No clear consensus has been reached on the alpha-adducin polymorphism (Gly460Trp) and essential hypertension risk. We performed a meta-analysis in an effort to systematically summarize the possible association.

METHODOLOGY/PRINCIPAL FINDINGS:

Studies were identified by searching MEDLINE and EMBASE databases complemented with perusal of bibliographies of retrieved articles and correspondence with original authors. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. We selected 22 studies that met the inclusion criteria including a total of 14303 hypertensive patients and 15961 normotensive controls. Overall, the 460Trp allele showed no statistically significant association with hypertension risk compared to Gly460 allele (P = 0.69, OR = 1.02, 95% CI 0.94-1.10, P(heterogeneity)<0.0001) in all subjects. Meta-analysis under other genetic contrasts still did not reveal any significant association in all subjects, Caucasians, East Asians and others. The results were similar but heterogeneity did not persist when sensitivity analyses were limited to these studies.

CONCLUSIONS/SIGNIFICANCE:

Our meta-analysis failed to provide evidence for the genetic association of α-adducin gene Gly460Trp polymorphism with hypertension. Further studies investigating the effect of genetic networks, environmental factors, individual biological characteristics and their mutual interactions are needed to elucidate the possible mechanism for hypertension in humans.

• Authors: Kuo Liu, Jielin Liu, Yan Huang, Ya Liu, Yuqing Lou, Zuoguang Wang, Hong Zhang, Shan Yan, Zhizhong Li, Shaojun Wen
• Journal: PloS one (PLoS One) Vol. 5 Issue 9 (Sep 28 2010) ISSN: 1932-6203 [Electronic] United States
• PMID: 20927398 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Calmodulin-Binding Proteins
• adducin

Topics

• Asian People (genetics)
• Blood Pressure
• Calmodulin-Binding Proteins (genetics)
• Case-Control Studies
• Genetic Predisposition to Disease
• Humans
• Hypertension (genetics, physiopathology)
• Mutation, Missense
• Polymorphism, Genetic
• Risk Factors
• White People (genetics)