Abstract |
A case of severe haemolytic disease of the fetus due to six rare alloantibodies is described. In a pregnant women at 23 weeks gestation after the finding of a positive indirect Coombs test maternal antibodies have been precisely identified and titrated: anti-I: 1/23, anti-c: 1/64, anti-S: 1/16, anti-Fya: 1/128, anti-M: 1/64, anti-Jka: 1/32000. Fetal blood group, free and red blood cell adherent antibodies have been investigated on fetal blood samples obtained by means of cord centesis. A compatible donor has been found. Severe fetal anemia has been corrected by ultrasound guided intrauterine transfusions (one abdominal and two intravascular transfusions) with positive outcome of the pregnancy.
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Authors | V Tantalo, E Rossi, G A Gianotti, R Morotti, G Zuliani, M Buscaglia, M Galligani |
Journal | Annali di ostetricia, ginecologia, medicina perinatale
(Ann Ostet Ginecol Med Perinat)
1990 Sep-Oct
Vol. 111
Issue 5
Pg. 321-5
ISSN: 0300-0087 [Print] Italy |
Vernacular Title | Malattia emolitica fetale in una paziente immunizzata da sei anticorpi: diagnosi e trattamento. |
PMID | 2092607
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Blood Transfusion, Intrauterine
- Erythroblastosis, Fetal
(immunology, therapy)
- Female
- Humans
- Infant, Newborn
- Isoantibodies
(analysis)
- Pregnancy
- Ultrasonography, Prenatal
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