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[Ranolazine--an additional anti-anginal drug].

Abstract
Ranolazine is a new drug for use in patients with stable angina pectoris. Unlike other antianginal drugs ranolazine does not alter heart rate or systemic blood pressure. Inhibition of the persistent or late sodium current (I(Na,late)) by ranolazine reduces [Na(+) ](i)-dependent Ca(2+) overload and the effects of ischaemia. Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.
AuthorsG Michels, M Kochanek, U C Hoppe
JournalDeutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 135 Issue 41 Pg. 2037-40 (Oct 2010) ISSN: 1439-4413 [Electronic] Germany
Vernacular TitleRanolazin - ein ergänzendes Antianginosum.
PMID20925013 (Publication Type: English Abstract, Journal Article, Review)
Copyright© Georg Thieme Verlag KG Stuttgart · New York.
Chemical References
  • Acetanilides
  • Enzyme Inhibitors
  • Piperazines
  • Ranolazine
Topics
  • Acetanilides (adverse effects, pharmacokinetics, therapeutic use)
  • Angina Pectoris (blood, drug therapy)
  • Atrial Fibrillation (blood, drug therapy)
  • Biological Availability
  • Blood Pressure (drug effects)
  • Double-Blind Method
  • Enzyme Inhibitors (adverse effects, pharmacokinetics, therapeutic use)
  • Heart Failure, Diastolic (blood, drug therapy)
  • Heart Rate (drug effects)
  • Humans
  • Metabolic Clearance Rate (physiology)
  • Piperazines (adverse effects, pharmacokinetics, therapeutic use)
  • Randomized Controlled Trials as Topic
  • Ranolazine

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