Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial.

Abstract

BACKGROUND:

Serum cytokine concentrations may reflect inflammatory processes occurring during the development of colorectal neoplasms. Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation.

METHODS:

Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the association between serum concentrations of interleukin (IL) β, 2, 8, 10, 12p70, granulocyte macrophage colony stimulating factor, interferon-γ, and tumour necrosis factor-α, measured over time, flavonol intake, estimated from a flavonol database used in conjunction with a food frequency questionnaire, and adenoma recurrence in 872 participants from the intervention arm of the Polyp Prevention Trial.

RESULTS:

Decreased IL-2 concentration during the trial increased the risk of any adenoma recurrence (4th vs 1st quartile, OR=1.68, 95% CI=1.13-2.49), whereas decreased IL-1β or IL-10 reduced the risk of advanced adenoma recurrence (OR=0.37, 95% CI=0.15-0.94; OR=0.39, 95% CI=0.15-0.98, respectively). Individuals with flavonol intake above the median (29.7 mg per day) and decreased cytokine concentrations had the lowest risk of advanced adenoma recurrence.

CONCLUSION:

Overall, no consistent associations were observed between serum cytokine profile and colorectal adenoma recurrence; however, decreased cytokine concentrations during high flavonol consumption may indicate prevention of colorectal neoplasms.

• Authors: G Bobe, G Murphy, P S Albert, L B Sansbury, E Lanza, A Schatzkin, N H Colburn, A J Cross
• Journal: British journal of cancer (Br J Cancer) Vol. 103 Issue 9 Pg. 1453-61 (Oct 26 2010) ISSN: 1532-1827 [Electronic] England
• PMID: 20924374 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)

Chemical References

• Cytokines
• Flavonols
• Interleukins

Topics

• Adenoma (blood, prevention & control)
• Aged
• Clinical Trials as Topic
• Colorectal Neoplasms (blood, prevention & control)
• Cytokines (blood)
• Diet
• Female
• Flavonols (administration & dosage)
• Humans
• Interleukins (blood)
• Male
• Middle Aged
• Recurrence