Abstract | OBJECTIVE: METHODS: We assessed plasma [corrected] BDNF immunoreactivity in 15 patients with ES, 12 patients with PNES, and 17 healthy volunteers. Plasma [corrected] BDNF levels were measured using an enzyme-linked immunoassay. RESULTS: Healthy controls showed higher BDNF levels (4,289 ± 1,810 pg/mL) compared to patients with PNES (1,033 ± 435 pg/mL) (p < 0.001). However, unexpectedly, healthy controls also showed higher levels of BDNF compared to patients with ES without comorbid MDD (977 ± 565 pg/mL) (p < 0.001). CONCLUSIONS: Unlike children, adults with epilepsy appear to have decreased levels of plasma [corrected] BDNF. Reduced plasma [corrected] BDNF levels can be used to differentiate adult patients with ES or PNES from healthy controls. Further human studies are needed to better understand the pathophysiology explaining the decreased plasma [corrected] BDNF levels found in epilepsy and in PNES.
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Authors | W C LaFrance Jr, K Leaver, E G Stopa, G D Papandonatos, A S Blum |
Journal | Neurology
(Neurology)
Vol. 75
Issue 14
Pg. 1285-91
(Oct 05 2010)
ISSN: 1526-632X [Electronic] United States |
PMID | 20921514
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Brain-Derived Neurotrophic Factor
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Topics |
- Adult
- Aged
- Analysis of Variance
- Brain-Derived Neurotrophic Factor
(blood, genetics)
- Electroencephalography
(methods)
- Enzyme-Linked Immunosorbent Assay
(methods)
- Epilepsy
(blood)
- Female
- Humans
- Male
- Middle Aged
- Psychophysiologic Disorders
(blood, complications)
- Seizures
(blood, complications, psychology)
- Young Adult
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