Influence of laminarin polysaccahrides on oxidative damage.

Abstract

Laminarin is a tropical plant traditionally used in Chinese medicine. In this experiment, Laminarin polysaccharides were analysed using GC-MS method and result showed that the polysaccharides contained mannose (3.27%), arabinose (8.61%), glucose (4.23%), galactose (12.12%), fucose (46.93%). Laminarin polysaccharides were tested to evaluate their effect on lung oxidative stress and lipid peroxidation in rats. The animal were divided into model and polysaccharides-treated animal. Laminarin polysaccharides were administered by gavage over a 14-day period. The results indicated that Laminarin polysaccharides significantly normalized catalase (CAT) activity (P<0.01), increased glutathione peroxidase (GPx) activity (P<0.05), superoxide dismutase (SOD) activity and reduced malondialdehyde (MDA) concentrations in animal. It could be concluded that Laminarin polysaccharides appeared to be more effective in reducing sepsis-induced oxidative stress, lipid peroxidation in animal.

• Authors: Daye Cheng, Bin Liang, Mingxin Li, Minglin Jin
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 48 Issue 1 Pg. 63-6 (Jan 01 2011) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 20920522 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Glucans
• Polysaccharides
• Malondialdehyde
• laminaran
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase
• Caspase 3
• Glutathione

Topics

• Animals
• Caspase 3 (metabolism)
• Catalase (metabolism)
• Female
• Gas Chromatography-Mass Spectrometry
• Glucans
• Glutathione (metabolism)
• Glutathione Peroxidase (metabolism)
• Lung (drug effects, enzymology)
• Male
• Malondialdehyde (metabolism)
• Oxidative Stress (drug effects)
• Polysaccharides (analysis, pharmacology)
• Rats
• Rats, Sprague-Dawley
• Superoxide Dismutase (metabolism)