Abstract |
An extracapsular cataract extraction was performed on both eyes of 24 rabbits. Irrigation for 10 min of the capsular bag of the left (test) eye with 8-12 cm3 of 1 litre of BSS-plus to which had been added 50 mg of 5-fluorouracil significantly inhibited proliferation of the anterior capsular epithelium as compared with the right (control) eyes identically treated except for the omission of 5-fluorouracil (p less than 0.001). Corneal endothelial counts did not differ significantly. A reduction in opacification of the posterior capsule is expected from 5-fluorouracil treatment.
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Authors | J M Ruíz, M Medrano, J L Alió |
Journal | Ophthalmic research
(Ophthalmic Res)
Vol. 22
Issue 4
Pg. 201-8
( 1990)
ISSN: 0030-3747 [Print] Switzerland |
PMID | 2089339
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Cataract
(prevention & control)
- Cataract Extraction
- Cell Count
(drug effects)
- Cell Division
(drug effects)
- Endothelium, Corneal
(drug effects)
- Epithelium
(drug effects)
- Fluorouracil
(therapeutic use, toxicity)
- Lens Capsule, Crystalline
(drug effects)
- Rabbits
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