Antineoplastic agents, 177. Isolation and structure of phyllanthostatin 6.

Abstract

The isolation and structural elucidation of a new Phyllanthus glycoside, phyllanthostatin 6 [7], was summarized. Phyllanthostatin 6 [7] was isolated from the roots of Phyllanthus acuminatus (Euphorbiaceae) and was found to inhibit (ED50 = 0.35 micrograms/ml) growth of the murine P-388 lymphocytic leukemia cell line. Two other new constituents were shown to be didesacetylphyllanthostatin 3 [9] and descinnamoylphyllanthocindiol [10]. Structure determinations were achieved employing hrfabms and 2D-nmr spectroscopy. Application of an hplc separation technique to the Phyllanthus glycosides and development of a new isolation procedure for the major antineoplastic constituent, phyllanthoside [1], are also described.

• Authors: G R Pettit, D E Schaufelberger, R A Nieman, C Dufresne, J A Saenz-Renauld
• Journal: Journal of natural products (J Nat Prod) 1990 Nov-Dec Vol. 53 Issue 6 Pg. 1406-13 ISSN: 0163-3864 [Print] United States
• PMID: 2089115 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Benzofurans
• Glycosides
• Pyrans
• Sesquiterpenes
• Spiro Compounds
• phyllanthostatin 6
• didesacetylphyllanthostatin 3
• descinnanoylphyllanthocindiol
• phyllanthoside

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification)
• Benzofurans (chemistry, isolation & purification, pharmacology)
• Chromatography, High Pressure Liquid
• Glycosides (chemistry, isolation & purification, pharmacology)
• Leukemia P388 (drug therapy)
• Mice
• Molecular Structure
• Plants (analysis)
• Pyrans (isolation & purification)
• Sesquiterpenes
• Spectrum Analysis
• Spiro Compounds
• Tumor Cells, Cultured