[Hyperbaric oxygenation in combined treatment of interstitial cystitis].

Abstract

A total of 116 female patients with painful bladder syndrome/interstitial cystitis aged 32-78 years (mean age 56 +/- 2.4 years) entered the trial. They were divided into two groups according to treatment. Group 1 (n = 54) received 10-day combined conservative treatment consisting of antimicrobial drugs (if urinary infection was diagnosed), angioprotectors, mast cell activity stabilizers and bladder instillation with combined solution. Group 2 included 62 patients whose treatment included complex anti-inflammatory therapy in combination with HBO sessions (7-10 sessions in barochamber OKA-MT, 2.0 +/- 0.2 atm). Subjective (the disease course, pain intensity, 24-h and nocturnal pollakiuria, effective urine volume) and objective (microcirculation in the bladder wall) results were assessed. Dopplerograms revealed venous stagnation. Patients of group 2 had a persistent improvement of microcirculation in bladder mucosa as shown by better blood flow in the veins and arterioles. In group 1 the above improvement was less pronounced. Thus, HBO in combined treatment of interstitial cystitis improves treatment results and promotes long-term remission of the disease.

• Authors: D Iu Pushkar', A V Zaĭtsev, A P Gavrilenko, A B Matsaev, G R Kasian, K B Kolontarev, R F Farmanov
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2010 Jan-Feb Issue 1 Pg. 22-4 ISSN: 1728-2985 [Print] Russia (Federation)
• PMID: 20886727 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Topics

• Adult
• Aged
• Combined Modality Therapy
• Cystitis, Interstitial (drug therapy, physiopathology, therapy)
• Female
• Humans
• Hyperbaric Oxygenation (methods)
• Microcirculation (physiology)
• Middle Aged
• Pain (prevention & control)
• Pain Measurement
• Treatment Outcome
• Urinary Bladder (blood supply, physiopathology)