Abstract | BACKGROUND: METHODS: Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+E (4.5 ml/kg), and F+RW (35 ml/kg of Malbec RW containing 4.5 ml/kg E). E and RW were administered during the last 4 weeks of a 10-week period. RESULTS: RW administration to F rats was able to significantly decrease insulin resistance, mesenteric adipose tissue weight, and systolic blood pressure (SBP) compared to F group. F+E only reduced the SBP (P < 0.05 vs. F). F+RW also reduced aortic NAD(P)H-oxidase activity, NAD(P)H subunits Nox4 expression in mesenteric tissue, plasma thiobarbituric acid reactive substances ( TBARS), and recovered plasma total antioxidant activity (TAA) compared to F and F+E groups (P < 0.05). Adiponectin expression decreased, whereas resistin, vascular cell adhesion molecules-1 (VCAM-1), and nuclear factor-κB (NF-κB) expression and vascular remodeling in mesenteric arteries were higher in F than in C group (P < 0.05). Only RW was able to partially reverse the aforementioned alterations. CONCLUSION: In this study, Malbec RW, but not alcohol alone, improved the balance of adipocytokines and attenuated the oxidative stress and vascular inflammation in a model of MS, suggesting that nonalcohol components of RW are responsible for the beneficial effects.
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Authors | Marcela A Vazquez-Prieto, Nicolás F Renna, Emiliano R Diez, Valeria Cacciamani, Carina Lembo, Roberto M Miatello |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 24
Issue 2
Pg. 234-40
(Feb 2011)
ISSN: 1941-7225 [Electronic] United States |
PMID | 20885371
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adipokines
- Adiponectin
- Adipoq protein, rat
- Antioxidants
- Dietary Sucrose
- NF-kappa B
- Resistin
- Retn protein, rat
- Thiobarbituric Acid Reactive Substances
- Vascular Cell Adhesion Molecule-1
- Fructose
- Ethanol
- NADPH Oxidase 4
- NADPH Oxidases
- Nox4 protein, rat
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Topics |
- Abdominal Fat
(drug effects, metabolism, physiopathology)
- Adipokines
(metabolism)
- Adiponectin
(metabolism)
- Animals
- Antioxidants
(metabolism)
- Aorta
(drug effects, metabolism, physiopathology)
- Blood Pressure
- Dietary Sucrose
- Disease Models, Animal
- Ethanol
(administration & dosage)
- Fructose
- Insulin Resistance
- Male
- Metabolic Syndrome
(etiology, metabolism, physiopathology, prevention & control)
- NADPH Oxidase 4
- NADPH Oxidases
(metabolism)
- NF-kappa B
(metabolism)
- Oxidative Stress
(drug effects)
- Rats
- Rats, Wistar
- Resistin
(metabolism)
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Vascular Cell Adhesion Molecule-1
(metabolism)
- Wine
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