Abstract | BACKGROUND: EUS-guided ablation of pancreatic cysts is a minimally invasive technique with reported short-term, CT-defined cyst resolution rates of 33% to 79%. Follow-up results of image-defined, successful pancreatic cyst ablation are not known. OBJECTIVE: To determine the durability of successful cyst resolution after EUS-guided ethanol lavage. DESIGN: Prospective cohort study. SETTING: Two tertiary-care referral hospitals in the United States. PATIENTS: This study involved 12 patients with 1-to-5-cm, unilocular, pancreatic cysts that had previously resolved after ethanol lavage. INTERVENTIONS: Follow-up CT after cyst resolution. MAIN OUTCOME MEASUREMENTS: The presence or absence of residual pancreatic cysts by CT scanning after previous successful ablation. RESULTS: In a previously reported trial, we found that CT scanning documented pancreatic cyst resolution in 12 patients (33%) after one (n = 6) or two (n = 6) ethanol lavages. These 12 cysts (median diameter 18 mm; range 10-34 mm) were located in the head/uncinate of the pancreas in 6 patients (50%) and in the body of the pancreas in 6 patients (50%). The median cyst fluid carcinoembryonic antigen (CEA) level (available in 11 patients) was 463 ng/mL (range 1.6-64,550 ng/mL; normal, 0-2.5 ng/mL). Clinical diagnoses were mucinous cystic neoplasm (MCN) in 9 patients, intraductal papillary mucinous neoplasm in 1 patient, pseudocyst in 1 patient, and serous cystadenoma (SCA) in 1 patient. Follow-up CT in 3 patients (one each of MCN, SCA, and pseudocyst) after the initial diagnosis of cyst resolution was not available. For the remaining 9 patients (75%), follow-up CT performed in a median of 26 months (range 13-39 months) after initial documentation of cyst resolution demonstrated no evidence of cyst recurrence in any patient. LIMITATIONS: Loss to follow-up of some of the cohort. CONCLUSIONS: Follow-up after successful EUS-guided ethanol ablation of pancreatic cysts, including suspected mucinous cysts, suggests a durable, image-defined resolution. Longer follow-up in these patients is needed before considering these patients "cured" of their disease.
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Authors | John DeWitt, Christopher J DiMaio, William R Brugge |
Journal | Gastrointestinal endoscopy
(Gastrointest Endosc)
Vol. 72
Issue 4
Pg. 862-6
(Oct 2010)
ISSN: 1097-6779 [Electronic] United States |
PMID | 20883866
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright © 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Carcinoembryonic Antigen
- Ethanol
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Topics |
- Carcinoembryonic Antigen
(analysis)
- Catheter Ablation
(methods)
- Endosonography
- Ethanol
(administration & dosage)
- Follow-Up Studies
- Humans
- Pancreatic Cyst
(diagnostic imaging, therapy)
- Recurrence
- Therapeutic Irrigation
- Tomography, X-Ray Computed
- Treatment Outcome
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