Patients with
bleeding disorders are at a high risk of
bleeding complications during
surgical procedures.
Cyanoacrylates have been used successfully in many procedures and surgeries. This study was undertaken to evaluate the effectiveness of
Glubran 2 and
Glubran tissue skin adhesive (
Glubran Tiss) in patients with hereditary
bleeding disorders who underwent circumcision or dental extraction. Seven patients with congenital
bleeding disorders who underwent circumcision or dental extraction were evaluated during 2009. A historical control group was considered for comparison.
Glubran 2 acrylic glue was applied in cases of dental extraction and
Glubran Tiss in circumcision. The patients were followed up for 6 months to detect complications. Five patients had
hemophilia A, one patient had
hemophilia B, and one patient had
Bernard-Soulier syndrome; six were boys or men and one was a girl. Mean age was 15±8 years (range 5 to 25 years). The results in all patients under circumcision were good with significantly less factor consumption (P=0.043). But in patients who underwent dental extraction,
Glubran was effective only in a 5-year-old girl with mandibular premolar
tooth extraction, but not successful in a 21-year-old man with extraction of maxillary wisdom tooth. After 6 months of follow-up, no complications were observed in any patients. Our experiences in this small series of patients suggest that adjunct use of
Glubran Tiss, in addition to systemic replacement
therapy, can be effective in the control of
bleeding in patients with
hemophilia who undergo circumcision, and helps to lessen factor consumption. But, further studies with larger sample size are needed. However, our experience in using
Glubran in dental extraction was not successful.