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Mycobacterium massiliense BRA100 strain recovered from postsurgical infections: resistance to high concentrations of glutaraldehyde and alternative solutions for high level disinfection.

AbstractPURPOSE:
To evaluate the minimum inhibitory concentration (MIC) of GTA against these microorganisms and alternative disinfectants for high-level disinfection (HLD).
METHODS:
Reference mycobacteria and clinical M. massiliense strains were included in this study. Active cultures were submitted to susceptibility qualitative tests with GTA dilutions (ranging from 1.5% to 8%), and commercial orthophthaldehyde (OPA) and peracetic acid (PA)-based solutions, during the period of exposure as recommended by National Agency of Sanitary Surveillance for HLD.
RESULTS:
All reference and M. massiliense non-BRA100 strains, recovered from sputum, were susceptible to any GTA concentration, OPA and PA solutions. M. massiliense BRA100 strains presented MIC of 8% GTA and were susceptible to OPA and PA.
CONCLUSION:
M. massiliense BRA100 strain is resistant to high GTA concentrations (up to 7%), which proves that this product is non-effective against specific rapidly growing mycobacteria and should be substituted by OPA or PA-based solutions for HLD.
AuthorsNádia Suely de Oliveira Lorena, Marcos Bettini Pitombo, Patrícia Barbur Côrtes, Maria Cristina Araújo Maya, Marlei Gomes da Silva, Ana Carolina da Silva Carvalho, Fábrice Santana Coelho, Neide Hiromi Tokumaru Miyazaki, Elizabeth Andrade Marques, Alberto Chebabo, Andréa D'Avila Freitas, Otília Lupi, Rafael Silva Duarte
JournalActa cirurgica brasileira (Acta Cir Bras) Vol. 25 Issue 5 Pg. 455-9 (Oct 2010) ISSN: 1678-2674 [Electronic] Brazil
PMID20877958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aldehydes
  • Disinfectants
  • Peracetic Acid
  • Glutaral
Topics
  • Aldehydes (pharmacology)
  • Disinfectants (pharmacology)
  • Drug Resistance, Bacterial (drug effects)
  • Glutaral (administration & dosage, pharmacology)
  • Humans
  • Microbial Sensitivity Tests
  • Mycobacterium (classification, drug effects, isolation & purification)
  • Peracetic Acid (pharmacology)
  • Postoperative Complications (microbiology)

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