Cytotoxicity on L1210 leukemic cells of beta-amanitin-concanavalin A and phallacidin-concanavalin A conjugates.

Abstract

The conjugates beta-amanitin-concanavalin A and phallacidin concanavalin A were tested for direct cytotoxicity on L1210 lymphocytic leukemia cells by a combined in vitro-in vivo bioassay. Both conjugates exerted strong direct cytotoxicity on the tumour cells.

• Authors: Z Zhelev, M Ilarionova, A Zheleva, C Alexiev, K Halacheva, D Todorov
• Journal: Toxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 28 Issue 11 Pg. 1360-3 ( 1990) ISSN: 0041-0101 [Print] England
• PMID: 2087697 (Publication Type: Journal Article)

Chemical References

• Amanitins
• Cytotoxins
• Immunotoxins
• Peptides, Cyclic
• Concanavalin A
• beta-amanitin
• phallacidin

Topics

• Amanitins (toxicity)
• Animals
• Cell Survival
• Concanavalin A
• Cytotoxins (toxicity)
• Immunotoxins
• Leukemia L1210
• Peptides, Cyclic (toxicity)
• Tumor Cells, Cultured