Abstract | OBJECTIVE: DESIGN: Randomised placebo controlled study. SETTING: Tertiary level neonatal intensive care unit. SAMPLE: 40 infants undergoing primary eye examination for ROP screening. INTERVENTION: The control group were swaddled, and received 0.2 ml of sterile water given by mouth using a syringe and a soother. The intervention group were swaddled, and received 0.2 ml of sucrose 24% given by mouth using a syringe and a soother. RESULTS: 40 infants were included in the study. There was no difference in mean gestational age at birth, mean birth weight or corrected gestational age at first examination between both groups. The sucrose group had a significantly lower median Neonatal Pain, Agitation and Sedation Scale (N-PASS) score during ROP screening, initially following insertion of the speculum (6.5 vs 5, p=0.02) and subsequently during scleral indentation (9.5 vs 7.5, p=0.03). Fewer infants experienced episodes of desaturations or bradycardia in the intervention group (1 vs 4, p=0.18). CONCLUSION: ROP screening is a necessary but recognised painful procedure. Sucrose combined with NNS and swaddling reduced the behavioural and physiological pain responses. However, pain scores remained consistently high and appropriate pain relief for ROP screening remains a challenge.
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Authors | A O'Sullivan, M O'Connor, D Brosnahan, K McCreery, E M Dempsey |
Journal | Archives of disease in childhood. Fetal and neonatal edition
(Arch Dis Child Fetal Neonatal Ed)
Vol. 95
Issue 6
Pg. F419-22
(Nov 2010)
ISSN: 1468-2052 [Electronic] England |
PMID | 20876596
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Administration, Oral
- Analgesia
(methods)
- Analgesics
(administration & dosage)
- Female
- Humans
- Infant Care
(methods)
- Infant, Newborn
- Infant, Premature
- Intensive Care, Neonatal
(methods)
- Male
- Neonatal Screening
(adverse effects, methods)
- Pacifiers
- Pain
(etiology, prevention & control)
- Pain Measurement
(methods)
- Physical Examination
(adverse effects, methods)
- Prospective Studies
- Retinopathy of Prematurity
(diagnosis)
- Sucrose
(administration & dosage)
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