Effect of structure on tumor specificity of alicyclic alpha-amino acids.

Abstract

The selective affinity of [carboxyl-11C]-1-aminocyclopentanecarboxylic acid (ACPC) for tumor tissue has led us to study the tumor-localizing characteristics of a series of alicyclic alpha-amino acid analogs of ACPC. The tissue distributions of [14C]-1-aminocyclopropanecarboxylic acid, 1-aminocyclobutanecarboxylic acid (ACBC), 1-aminocyclohexanecarboxylic acid, 1-amino-2-methylcyclopentanecarboxylic acid were compared with that of ACPC in Buffalo rats bearing Morris 5123C hepatomas. ACPC and ACBC were found to have significantly higher tumor-to-nontumor concentration ratios than the other four amino acids. ACBC generally had higher tumor-to-nontumor ratios than did ACPC, significantly so for muscle, kidney, and testis and marginally so for blood. These results suggest that [carboxyl-11C]ACBC may be a better agent than [carboxyl-11C]ACPC for tumor imaging by positron tomography.

• Authors: L C Washburn, T T Sun, J B Anon, R L Hayes
• Journal: Cancer research (Cancer Res) Vol. 38 Issue 8 Pg. 2271-3 (Aug 1978) ISSN: 0008-5472 [Print] United States
• PMID: 208763 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amino Acids
• Amino Acids, Cyclic
• Cyclobutanes
• Cyclohexanecarboxylic Acids
• Cyclopropanes
• Cycloleucine
• 1-aminocyclobutanecarboxylic acid
• 1-aminocyclohexanecarboxylic acid
• 1-amino-2-methylcyclopentanecarboxylic acid

Topics

• Amino Acids (metabolism)
• Amino Acids, Cyclic
• Animals
• Carcinoma, Hepatocellular (metabolism)
• Cyclobutanes (metabolism)
• Cyclohexanecarboxylic Acids (metabolism)
• Cycloleucine (analogs & derivatives, metabolism)
• Cyclopropanes (metabolism)
• Liver Neoplasms (metabolism)
• Male
• Neoplasms (diagnostic imaging)
• Neoplasms, Experimental (metabolism)
• Radionuclide Imaging
• Rats
• Structure-Activity Relationship
• Tissue Distribution
• Tomography, X-Ray Computed