Antiarrhythmic activity of novel S-enantiomers of pyrrolidin-2-one derivatives with adrenolytic properties.

Abstract

A six new analogs of MG-1(S), 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, with adrenolytic properties were tested for electrocardiographic and antiarrhythmic activity in model ventricular arrhythmias associated with coronary artery occlusion and reperfusion in the non-working isolated perfused rat heart and additionally in barium chloride-induced arrhythmia in vivo. All tested compounds slightly decreased the heart rate, prolonged P-Q, Q-T intervals and QRS complex. The antiarrhythmic effects of all tested compounds were weaker than the reference compound MG-1(S).

• Authors: Jacek Sapa
• Journal: Acta poloniae pharmaceutica (Acta Pol Pharm) 2010 Sep-Oct Vol. 67 Issue 5 Pg. 537-42 ISSN: 0001-6837 [Print] Poland
• PMID: 20873423 (Publication Type: Journal Article)

Chemical References

• Adrenergic Antagonists
• Anti-Arrhythmia Agents
• Pyrrolidinones

Topics

• Adrenergic Antagonists (pharmacology)
• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Electrocardiography (drug effects)
• Male
• Pyrrolidinones (pharmacology)
• Rats
• Rats, Wistar
• Stereoisomerism