Effect of a non-protein fraction from an extract of the inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin) on Meth A-induced delayed type hypersensitivity.

Abstract

The effect of a non-protein fraction from an extract of inflamed skin of rabbits inoculated with vaccinia virus (Neurotropin, NSP) was studied on Meth A tumor-induced delayed type hypersensitivity (Meth A-DTH) in BALB/c mice. NSP enhanced the Meth A-DTH. NSP also enhanced the DTH suppressed with 5-fluorouracil (5-FU). Moreover, NSP inhibited the fatal effect of 5-FU and restored the decrease of body weight caused by 5-FU. However, NSP reduced partially but significantly the suppression of the tumor growth by 5-FU. NSP may be useful for cancer treatment in combination with chemotherapeutic agents, if NSP does not inhibit their antitumor activity.

• Authors: H Mori, Y Kurimoto, Q A Xu, A Koda
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 54 Issue 4 Pg. 468-72 (Dec 1990) ISSN: 0021-5198 [Print] Japan
• PMID: 2087010 (Publication Type: Journal Article)

Chemical References

• Polysaccharides
• Tissue Extracts
• neurotropin
• Fluorouracil

Topics

• Animals
• Fluorouracil (antagonists & inhibitors, pharmacology)
• Hypersensitivity, Delayed (chemically induced)
• Mice
• Mice, Inbred BALB C
• Polysaccharides (pharmacology)
• Rabbits
• Tissue Extracts (pharmacology)