Abstract |
Bordetella isolates in the Saint Petersburg region have been monitored since 1998. Over the past ten years, concomitant with the increase in pertussis whole-cell vaccine coverage, the incidence of whooping cough has decreased. However, this decrease exists only for Bordetella pertussis infections, as the incidence of Bordetella parapertussis confirmed cases has remained stable, suggesting that pertussis-vaccine-induced immunity is not protective against parapertussis, as expected. B. pertussis and B. parapertussis clinical isolates were analyzed using serotyping, immunoblotting, pulsed-field gel electrophoresis of chromosomal DNA (after digestion with XbaI) and sequencing of virulence genes. The bacterial population is now similar to that observed in other European countries.
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Authors | Natalia Kurova, Elisabeth Njamkepo, Delphine Brun, Galina Tseneva, Nicole Guiso |
Journal | Research in microbiology
(Res Microbiol)
Vol. 161
Issue 10
Pg. 810-5
(Dec 2010)
ISSN: 1769-7123 [Electronic] France |
PMID | 20870020
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved. |
Chemical References |
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Topics |
- Bacterial Typing Techniques
- Bordetella Infections
(epidemiology, microbiology)
- Bordetella parapertussis
(classification, isolation & purification)
- Bordetella pertussis
(classification, isolation & purification)
- Child
- Child, Preschool
- Cluster Analysis
- Electrophoresis, Gel, Pulsed-Field
- Humans
- Immunoblotting
- Incidence
- Infant
- Molecular Epidemiology
- Molecular Typing
- Russia
(epidemiology)
- Sequence Analysis, DNA
- Serotyping
- Virulence Factors
(genetics)
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