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Survival after diphenhydramine ingestion with hemodialysis in a toddler.

Abstract
A 13-month-old male who ingested 20 diphenhydramine (25 mg) tablets presented with seizures and ultimately progressed to status epilepticus and wide-complex tachycardia. Due to worsening clinical course, hemodialysis was performed with temporal resolution of his symptoms. Hemodialysis may be considered in critically ill diphenhydramine overdoses not responsive to conventional supportive care.
AuthorsNathanael J McKeown, Patrick L West, Robert G Hendrickson, B Zane Horowitz
JournalJournal of medical toxicology : official journal of the American College of Medical Toxicology (J Med Toxicol) Vol. 7 Issue 2 Pg. 147-50 (Jun 2011) ISSN: 1937-6995 [Electronic] United States
PMID20865465 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Hypnotics and Sedatives
  • Diphenhydramine
  • Midazolam
Topics
  • Diphenhydramine (poisoning)
  • Humans
  • Hypnotics and Sedatives (poisoning, therapeutic use)
  • Infant
  • Injections, Intramuscular
  • Male
  • Midazolam (therapeutic use)
  • Poisoning (etiology, physiopathology, therapy)
  • Renal Dialysis
  • Seizures (chemically induced, drug therapy, physiopathology)
  • Status Epilepticus (chemically induced)
  • Tachycardia (chemically induced, physiopathology)
  • Treatment Outcome

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