Abstract | INTRODUCTION: METHODS: A series of 229 uterine endometrioid adenocarcinomas from a previously well-characterized cohort were re-evaluated for expression of the inhibin-βA subunit and correlated with several clinicopathological characteristics and clinical outcomes. Both staining intensity and analyses of a semi-quantitative score were used to evaluate inhibin-βA immunolabeling. RESULTS: The inhibin-βA subunit was present in malignant endometrioid uterine tissue, and was associated with myometrial invasion (p < 0.05). Univariate survival analysis demonstrated no differences in progression-free survival, cause-specific survival and overall survival for inhibin-βA using the median of the calculated semi-quantitative score. However, patients with a positive inhibin-βA, as identified by staining intensity, demonstrated significantly worse cause-specific survival (p < 0.05). CONCLUSIONS: Evaluation of staining intensity revealed better cause-specific survival in patients with negative or low inhibin-βA immunolabeling intensity. Therefore, although of some use, semi-quantification of immunohistochemical reactions might not be definitive for evaluation of the inhibin-βA subunit as a prognostic marker in endometrial cancer patients. Therefore, staining intensity evaluation should be performed in addition to semi-quantitative analysis. Further research is warranted to elucidate the possible implications of inhibin-βA and endometrial carcinogenesis.
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Authors | Ioannis Mylonas |
Journal | Archives of gynecology and obstetrics
(Arch Gynecol Obstet)
Vol. 284
Issue 2
Pg. 467-76
(Aug 2011)
ISSN: 1432-0711 [Electronic] Germany |
PMID | 20865419
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- inhibin beta A subunit
- Inhibin-beta Subunits
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(metabolism)
- Carcinoma, Endometrioid
(metabolism, pathology, therapy)
- Disease-Free Survival
- Endometrial Neoplasms
(metabolism, pathology, therapy)
- Female
- Humans
- Immunohistochemistry
- Inhibin-beta Subunits
(metabolism)
- Kaplan-Meier Estimate
- Middle Aged
- Neoplasm Invasiveness
- Proportional Hazards Models
- ROC Curve
- Retrospective Studies
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