Dyslipidemia of mothers with familial hypercholesterolemia deteriorates lipids in adult offspring.

Abstract

OBJECTIVE:

It is unknown whether elevated maternal low-density lipoprotein cholesterol (LDL-C) levels lead to dyslipidemia in the offspring. Because this could have important consequences for cardiovascular prevention in mother and child, we explored the relationship between maternal familial hypercholesterolemia (FH) and lipids in adult offspring.

METHODS AND RESULTS:

In a large cohort of both Dutch and Canadian origin, we compared lipid profiles between patients, aged 18 to 85 years, who inherited FH maternally (n=1069) and those who inherited FH paternally (n=1270). This relationship was evaluated using multivariate regression analyses. Levels of total cholesterol (TC), LDL-C, and apolipoprotein B 100 (ApoB100) were significantly elevated in patients who inherited FH maternally compared with patients who inherited FH paternally (adjusted differences in TC: 0.156 mmol/L, P=0.037; LDL-C: 0.187 mmol/L, P=0.012; ApoB: 0.064 g/L, P=0.022).

CONCLUSIONS:

Our data show that maternal hereditary hypercholesterolemia slightly increases TC, LDL-C, and ApoB levels in their offspring later in life. Although the molecular mechanisms underlying these observations still require elucidation, our data suggest that maternal hypercholesterolemia during pregnancy may program lipid metabolism to a certain extent in the fetus.

• Authors: Anouk van der Graaf, Maud N Vissers, Daniel Gaudet, Diane Brisson, Suthesh Sivapalaratnam, Tessa J Roseboom, Angelique C M Jansen, John J P Kastelein, Barbara A Hutten
• Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 30 Issue 12 Pg. 2673-7 (Dec 2010) ISSN: 1524-4636 [Electronic] United States
• PMID: 20864670 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoproteins B
• Biomarkers
• Cholesterol, LDL
• Cholesterol

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Apolipoproteins B (blood)
• Biomarkers (blood)
• Cholesterol (blood)
• Cholesterol, LDL (blood)
• Female
• Genetic Predisposition to Disease
• Heredity
• Humans
• Hyperlipoproteinemia Type II (blood, genetics)
• Lipid Metabolism (genetics)
• Male
• Middle Aged
• Netherlands
• Pedigree
• Phenotype
• Pregnancy
• Prenatal Exposure Delayed Effects (genetics)
• Quebec
• Regression Analysis
• Retrospective Studies
• Risk Assessment
• Risk Factors
• Up-Regulation
• Young Adult