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The quinoxaline anti-tumor agent (R+)XK469 inhibits neuroblastoma tumor growth.

Abstract
The quinoxaline anti-tumor agent (R+)XK469 mediates its effects by topoisomerase IIB inhibition. This report describes a 14-year old with relapsed neuroblastoma who experienced disease stabilization for 14 months while receiving (R+)XK469 monotherapy. Due to this favorable response, laboratory studies were undertaken to determine efficacy in the preclinical setting. (R+)XK469 inhibited proliferation, caused G(2) cell cycle arrest of neuroblastoma cells in vitro, and inhibited growth of neuroblastoma xenograft tumors. These preclinical results, coupled with the favorable clinical response, demonstrate that (R+)XK469 and similar anti-tumor agents may be effective in the treatment of high-risk neuroblastoma and warrant further testing.
AuthorsNisha C Kakodkar, Radhika Peddinti, Morris Kletzel, Yufeng Tian, Lisa J Guerrero, Samir D Undevia, David Geary, Alexandre Chlenski, Qiwei Yang, Helen R Salwen, Susan L Cohn
JournalPediatric blood & cancer (Pediatr Blood Cancer) Vol. 56 Issue 1 Pg. 164-7 (Jan 2011) ISSN: 1545-5017 [Electronic] United States
PMID20860039 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Quinoxalines
  • XK 469
Topics
  • Adolescent
  • Antineoplastic Agents (pharmacology)
  • Cell Cycle (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Fatal Outcome
  • Humans
  • Neoplasm Metastasis
  • Neuroblastoma (drug therapy, pathology)
  • Quinoxalines (pharmacology, therapeutic use)
  • Treatment Outcome
  • Xenograft Model Antitumor Assays

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