Brief overview of single-dose therapy for uncomplicated urinary tract infections.

The published studies of the use of single-dose antimicrobial therapy for the treatment of urinary tract infection have been reviewed. In women a single dose of any of several antimicrobial agents is as effective as a course of treatment for uncomplicated urinary tract infections caused by Escherichia coli. Trimethoprim or co-trimoxazole are currently the preferred agents for single-dose therapy. Fosfomycin trometamol and the 4-quinolones are promising agents. Failure of single-dose therapy may prove to be a simple guide as to the need for further urinary tract investigation or more intensive therapy. Single-dose antimicrobial therapy is now the treatment of choice for uncomplicated urinary tract infections in general practice.
AuthorsR R Bailey
JournalChemotherapy (Chemotherapy) Vol. 36 Suppl 1 Pg. 27-30 ( 1990) ISSN: 0009-3157 [Print] SWITZERLAND
PMID2085985 (Publication Type: Journal Article, Review)
Chemical References
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Trimethoprim
  • Bacteriuria (drug therapy)
  • Cystitis (drug therapy)
  • Drug Administration Schedule
  • Female
  • Humans
  • Trimethoprim (administration & dosage, therapeutic use)
  • Trimethoprim, Sulfamethoxazole Drug Combination (administration & dosage, therapeutic use)
  • Urinary Tract Infections (drug therapy)

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