Matrix metalloproteinase-9 (mmp-9) in children with dengue virus infection.

Abstract

The purpose of this study was to investigate the role of matrix metalloproteinase-9 (MMP-9) in the pathogenesis of vascular leakage in patients with dengue virus infection. Serum samples from 24 children with serologically confirmed dengue virus infection (dengue fever [DF], 16; dengue hemorrhagic fever [DHF], 8; age, 9.5+/-2.4 years; 67% male] were analyzed for MMP-9 during the febrile and toxic stages and at follow-up. Serum samples obtained from 7 healthy children were used as controls. Serum MMP-9 levels in patients with dengue virus infection were found to be lower at the febrile (227.0+/-186.9 ng/ml) and toxic stages (150.9+/-151.7 ng/ml) than at follow-up (424.5+/-227.8 ng/ml) or in the control group (393.3+/-125.9 ng/ml, P<0.001 by one-way ANOVA). There was no significant difference between MMP-9 levels in patients with DHF and those with DF at any stage of the disease. In conclusion, MMP-9 levels are reduced during the febrile and toxic stages of dengue virus infection.

• Authors: Nipasiri Voraphani, Apichai Khongphatthanayothin, Karakade Srikaew, Praewpilai Tontulawat, Yong Poovorawan
• Journal: Japanese journal of infectious diseases (Jpn J Infect Dis) Vol. 63 Issue 5 Pg. 346-8 (Sep 2010) ISSN: 1884-2836 [Electronic] Japan
• PMID: 20859002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Matrix Metalloproteinase 9

Topics

• Analysis of Variance
• Case-Control Studies
• Child
• Dengue (enzymology)
• Dengue Virus
• Female
• Fever (enzymology, virology)
• Humans
• Male
• Matrix Metalloproteinase 9 (blood)
• Severe Dengue (enzymology)