In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone.
Abstract | OBJECTIVES: To evaluate the in vivo antibacterial efficacy of nemonoxacin, a novel C8-methoxy non-fluorinated quinolone in murine systemic and local infection models. METHODS: The efficacy of nemonoxacin in systemic infections was evaluated in mouse peritonitis models using isolates of methicillin-susceptible Staphylococcus aureus (MSSA, n=1), methicillin-resistant S. aureus (MRSA, n=1), methicillin- and levofloxacin-resistant Staphylococcus capitis ( levofloxacin-resistant MRSC, n=1), penicillin-intermediate Streptococcus pneumoniae (PISP, n=1), penicillin-resistant S. pneumoniae (PRSP, n=2), Enterococcus faecalis (n=2, including 1 vancomycin-resistant Enterococcus, VRE) and Escherichia coli (n=3). The local infections included mouse pulmonary infections caused by PRSP (n=1), Klebsiella pneumoniae (n=1) and mouse ascending urinary tract infection caused by E. coli (n=1). RESULTS: In the mouse systemic infection model, nemonoxacin demonstrated potent activity against MSSA (ED(50) =2.08 mg/kg), MRSA (ED(50) =2.59 mg/kg), levofloxacin-resistant MRSC (ED(50) =2.52 mg/kg), PISP (ED(50) =5.47 mg/kg), PRSP (ED(50) =3.68-5.28 mg/kg) and E. coli (ED(50) =3.13-5.28 mg/kg), and moderate activity towards E. faecalis infection (ED(50) =8.48-15.16 mg/kg). The therapeutic efficacy of nemonoxacin was significantly higher (P<0.01) than that of levofloxacin in infections caused by Gram-positive isolates (MSSA, MRSA, levofloxacin-resistant MRSC, PISP, PRSP and E. faecalis), but less potent than that of levofloxacin against E. coli infection (P<0.01). Nemonoxacin in vivo efficacy results with Gram-positive isolates (2- to 5-fold ED(50) advantage over levofloxacin) are consistent with the MIC data (4- to 16-fold MIC advantage of nemonoxacin over levofloxacin). In the mouse pulmonary infection model, nemonoxacin showed potent activity towards PRSP (higher than levofloxacin) and K. pneumoniae (lower than levofloxacin) infections. In the mouse ascending urinary tract infection model, nemonoxacin exhibited potent activity against E. coli infection (lower than levofloxacin). CONCLUSIONS:
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Authors | Cong-Ran Li, Yi Li, Guo-Qing Li, Xin-Yi Yang, Wei-Xin Zhang, Ren-Hui Lou, Jing-Fang Liu, Min Yuan, Philip Huang, Shan Cen, Li-Yan Yu, Li-Xun Zhao, Jian-Dong Jiang, Xue-Fu You |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 65
Issue 11
Pg. 2411-5
(Nov 2010)
ISSN: 1460-2091 [Electronic] England |
PMID | 20858687
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Quinolones
- nemonoxacin
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Topics |
- Animals
- Anti-Bacterial Agents
(administration & dosage, pharmacology)
- Disease Models, Animal
- Female
- Gram-Negative Bacterial Infections
(drug therapy)
- Gram-Positive Bacterial Infections
(drug therapy)
- Male
- Mice
- Microbial Sensitivity Tests
- Pneumonia, Bacterial
(drug therapy)
- Quinolones
(administration & dosage, pharmacology)
- Treatment Outcome
- Urinary Tract Infections
(drug therapy)
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