High expression level of EDIL3 in HCC predicts poor prognosis of HCC patients.

Abstract

AIM:

To determine the role of epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3) in pathogenesis of hepatocellular carcinoma (HCC) by investigating the EDIL3 expression in HCC and its prognostic value for HCC.

METHODS:

EDIL3 expression was detected in 101 HCC surgical tissue samples with immunohistochemistry method, and its relation with clinicopathologic features and prognosis of HCC patients was analyzed.

RESULTS:

EDIL3 was highly expressed in 48.5% of the HCC patients. Although the EDIL3 expression level did not correlate with any clinicopathological parameters, Kaplan-Meier survival analysis showed that high expression level of EDIL3 resulted in a significantly poor prognosis of HCC patients (log-rank test, P = 0.010). Multivariate Cox's analysis showed that the EDIL3 expression level was a significant and independent prognostic parameter for the overall survival rate of HCC patients (hazard ratio = 1.978, 95% confidence interval = 1.139-3.435, P = 0.015).

CONCLUSION:

High expression level of EDIL3 predicts poor prognosis of HCC patients. EDIL3 may be a potential target of antiangiogenic therapy for HCC.

• Authors: Jian-Cong Sun, Xiao-Ting Liang, Ke Pan, Hui Wang, Jing-Jing Zhao, Jian-Jun Li, Hai-Qing Ma, Yi-Bing Chen, Jian-Chuan Xia
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 16 Issue 36 Pg. 4611-5 (Sep 28 2010) ISSN: 2219-2840 [Electronic] United States
• PMID: 20857535 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Calcium-Binding Proteins
• Carrier Proteins
• Cell Adhesion Molecules
• EDIL3 protein, human

Topics

• Biomarkers, Tumor (metabolism)
• Calcium-Binding Proteins
• Carcinoma, Hepatocellular (diagnosis, metabolism, pathology)
• Carrier Proteins (metabolism)
• Cell Adhesion Molecules
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Prognosis
• Survival Rate