A predictive factor for the response to S-1 plus cisplatin in gastric cancer.

Abstract

AIM:

To prove that the protein expression level of thymidylate synthase is a predictive factor for the response to S-1/cisplatin (CDDP) chemotherapy in gastric cancer.

METHODS:

We measured the protein expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) in advanced gastric cancer. Before S-1/CDDP chemotherapy, tumor specimens from primary sites were obtained by endoscopic biopsy and analyzed by enzyme-linked immunosorbent assay. The chemotherapeutic effects on the primary sites were evaluated by endoscopic biopsy performed more than once after S-1/CDDP chemotherapy. The effects are a predictive factor for the response to S-1/CDDP chemotherapy in patients with advanced gastric cancer, as evaluated by endoscopic biopsy over time.

RESULTS:

The protein expression level of TS was significantly higher (P < 0.05) in the tumor than in the normal tissue, and significantly lower (P < 0.05) in the responders than in the non-responders. We were able to evaluate the correlation between changes in the protein expression levels of TS, DPD and OPRT and chemotherapeutic responses in 7 patients by assessing tumor tissues more than twice. In the responders, the protein expression level of TS was < 40 ng/mg protein. However, there were significant increases in the protein expression levels of TS (P < 0.01) and DPD (P < 0.05) after chemotherapy in 3 patients. In these cases, the patient assessment changed from "responder" to "non-responder". In the non-responders, the protein expression level of TS was > 40 ng/mg protein.

CONCLUSION:

We have confirmed that the protein expression level of TS is a predictive factor for the response to S-1/CDDP chemotherapy in patients with advanced gastric cancer.

• Authors: Ikuko Miyazaki, Takashi Kawai, Youji Harada, Fuminori Moriyasu
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 16 Issue 36 Pg. 4575-82 (Sep 28 2010) ISSN: 2219-2840 [Electronic] United States
• PMID: 20857529 (Publication Type: Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Dihydrouracil Dehydrogenase (NADP)
• Thymidylate Synthase
• Orotate Phosphoribosyltransferase
• Cisplatin
• Fluorouracil

Topics

• Adult
• Aged
• Antimetabolites, Antineoplastic (therapeutic use)
• Cisplatin (therapeutic use)
• Dihydrouracil Dehydrogenase (NADP) (metabolism)
• Drug Combinations
• Female
• Fluorouracil (metabolism, therapeutic use)
• Humans
• Male
• Middle Aged
• Orotate Phosphoribosyltransferase (metabolism)
• Oxonic Acid (therapeutic use)
• Stomach Neoplasms (blood, drug therapy, enzymology)
• Tegafur (therapeutic use)
• Thymidylate Synthase (blood)