Abstract | INTRODUCTION: METHODS: Fourteen patients suffering exclusively from migraine with typical aura (MA) and 11 healthy volunteers received a continuous intravenous infusion of 1.5 µg/min CGRP over 20 minutes. Headache and other migraine symptoms were scored every 10 minutes for one hour and self recorded hourly thereafter and until 13 hours post-infusion. RESULTS: CGRP infusion induced significantly more delayed headaches in MA patients (12 out of 14) than in controls (2 out of 11) (p = 0.001). Furthermore, significantly more MA patients (57%; 8 out of 14) fulfilled criteria for an experimentally induced migraine attack after CGRP than controls (0%; 0 out of 11) (P = 0.003). Four patients (28%) reported aura symptoms after CGRP infusion. CONCLUSION: CGRP triggered migraine-like attacks without aura in patients suffering exclusively from MA. It also triggered a typical aura in 28% of the patients. These data indicate similar neurobiological pathways responsible for triggering migraine headache in MA and MO patients, and suggest differences between MA/MO and FHM.
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Authors | Jakob Møller Hansen, Anne Werner Hauge, Jes Olesen, Messoud Ashina |
Journal | Cephalalgia : an international journal of headache
(Cephalalgia)
Vol. 30
Issue 10
Pg. 1179-86
(Oct 2010)
ISSN: 1468-2982 [Electronic] England |
PMID | 20855363
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcitonin Gene-Related Peptide
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Topics |
- Adult
- Area Under Curve
- Calcitonin Gene-Related Peptide
(adverse effects, metabolism)
- Female
- Humans
- Male
- Middle Aged
- Migraine with Aura
(chemically induced, physiopathology)
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