In order to improve both safety and efficacy of
cancer chemotherapy of
titanocene dichloride and overcome the shortcomings such as instability and short half-life in the human body, we report a controlled release system of
titanocene dichloride by electrospun fiber and its in vitro antitumor activity against human lung
tumor spca-1 cells. The system was developed by electrospinning. The release profiles of
titanocene dichloride in PBS were researched by UV-Vis spectrophotometer. In vitro antitumor activities of the fibers were examined by MTT method.
Titanocene dichloride was well incorporated in biodegradable
poly(L-lactic acid) fibers. XRD results suggest that
titanocene dichloride exists in the amorphous form in the fibers. The controlled release of
titanocene dichloride can be gained for long time. MTT showed actual
titanocene dichloride content 40, 80, 160 and 240 mg/L from the fibers mat, cell growth inhibition rates of 11.2%, 22.1%, 44.2% and 68.2% were achieved, respectively. The
titanocene dichloride released has obvious inhibition effect against lung
tumor cells. The system has an effect of controlled release of
titanocene dichloride and may be used as an implantable anticancer
drug in clinical applications in the future.