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[Cardiac toxicity of 5-fluorouracil. Reflections on a case].

Abstract
The authors relate a case of spasm occurring during cisplatin and 6-fluorouracil combination chemotherapy. The cardiotoxicity of 5-F.U., and namely the risk of coronary spasm, has been known since 1969. However, few cases have been reported in France. Referring themselves to the case of interest and to literature sources, the authors review current pathogenic hypotheses and specify the precautions commanded by the prescription of any protocol that includes 5-F.U.
AuthorsP Perreau, H Jaulmes, C Bokowy, J E Demaldent
JournalAnnales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris (Ann Otolaryngol Chir Cervicofac) Vol. 107 Issue 8 Pg. 577-80 ( 1990) ISSN: 0003-438X [Print] France
Vernacular TitleToxicité cardiaque du 5-fluoro-uracile. Réflexions à propos d'un cas.
PMID2085263 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Chemical References
  • Fluorouracil
Topics
  • Coronary Vasospasm (chemically induced, etiology)
  • Fluorouracil (adverse effects, therapeutic use)
  • France
  • Humans
  • Male
  • Middle Aged

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