HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Technetium Tc 99m dimercaptosuccinic acid renal scintigraphy in children with acute pyelonephritis: correlation with other imaging tests.

Abstract
INTRODUCTION. Urinary tract infection is the most common serious bacterial infection in children. The aim of this study was to compare the value of different laboratory and imaging techniques in detecting renal involvement in acute pyelonephritis. MATERIALS AND METHODS. In a cross-sectional study of patients 1 month to 14 years of age diagnosed with urinary tract infection were examined with systemic inflammatory markers, renal ultrasonography, voiding cystourethrography (VCUG), and technetium Tc 99m dimercaptosuccinic acid ((99m)Tc-DMSA) renal scintigraphy. A total of 1467 pediatric patients were eligible for treatment of pyelonephritis. Evaluations included a complete blood count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), urinalysis, urine culture, and measurement of serum blood urea nitrogen and creatinine levels. RESULTS. The results of (99m)Tc-DMSA scans were normal in 20.2%, mild decreased cortical uptake in 45.0%, moderate decreased cortical uptake in 12.3%, severe decreased cortical uptake in 12.0%, and decreased cortical function plus irregularity or scar formation in 10.5%. Voiding cystourethrography showed vesicoureteral reflux in 25.9%. The sensitivity of (99m)Tc-DMSA for prediction of vesicoureteral reflux was 84.1% with a negative predictive value of 80.6%. Significant differences were found in the level of blood leukocyte count (P = .03), urine leukocyte count (P = .003), ESR (P = .008), and age (P = .04) between patients with normal and abnormal (99m)Tc-DMSA scan results. CONCLUSIONS. We found that in patient with clinical signs of pyelonephritis, (99m)Tc-DMSA renal scintigraphy can detect pyelonephritis more accurately than the other inflammatory and imaging tests.
AuthorsMasoumeh Mohkam, Saiid Maham, Afrand Rahmani, Ilana Naghi, Babak Otokesh, Hamid Raiiati, Nima Mohseni, Ahmad Reza Shamshiri, Mostafa Sharifian, Reza Dalirani, Ruhollah Ghazi, Majid Ahoopai
JournalIranian journal of kidney diseases (Iran J Kidney Dis) Vol. 4 Issue 4 Pg. 297-301 (Oct 2010) ISSN: 1735-8582 [Print] Iran
PMID20852370 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Radiopharmaceuticals
  • Technetium Tc 99m Dimercaptosuccinic Acid
Topics
  • Adolescent
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Diagnostic Imaging
  • Female
  • Humans
  • Infant
  • Male
  • Pyelonephritis (complications, diagnostic imaging)
  • ROC Curve
  • Radiography
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Urethra (diagnostic imaging)
  • Vesico-Ureteral Reflux (complications, diagnostic imaging)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: