l-histidine induces state-dependent memory deficit in mice mediated by H(1) receptor.

This study investigated the role of H(1) receptor in the state-dependent memory deficit induced by l-histidine (LH) in mice using Trial 1/2 protocol in the elevated plus-maze (EPM). The test was performed for two consecutive days: Trial 1 (T1) and Trial 2 (T2). Before both trials, mice received a combined injection i.p. of saline+saline (SAL/SAL), 500 mg/kg L-histidine+saline (LH/SAL), 500 mg/kg L-histidine+16 mg/kg chlorpheniramine (LH/CPA) or saline+16 mg/kg chlorpheniramine (SAL/CPA). The trials were performed in the EPM 10 min after the last injection. Each animal was placed in the center of the maze facing the open arm and had five minutes to explore it. On both days, test sessions were videotaped. The behavioral measures were scored from videotape. Data were analyzed based on Analysis of Variance (ANOVA) and the Fisher's LSD test. The data showed no effects on anxiety since there was no difference between the SAL/SAL and the other groups in Trial 1, respectively, open arm entries (OAE), open arm time (OAT) and their percentages (%OAE and %OAT). During Trial 2, OAE, OAT, %OAE and %OAT were reduced in mice treated with SAL/SAL, LH/CPA and SAL/CPA, while the group LH/SAL did not show any difference in these measures. No significant changes were observed in enclosed arm entries (EAE), an EPM index of general exploratory activity. Thus, it can be suggested that LH induces emotional memory deficit and the treatment with chlorpheniramine was able to revert this effect, suggesting this action of LH was mediated by the H(1) receptor.
AuthorsAnna Carolyna Gianlorenço, Azair Canto-de-Souza, Rosana Mattioli
JournalProgress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 35 Issue 1 Pg. 91-5 (Jan 15 2011) ISSN: 1878-4216 [Electronic] England
PMID20850492 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 Elsevier Inc. All rights reserved.
Chemical References
  • Histamine H1 Antagonists
  • Receptors, Histamine H1
  • Chlorpheniramine
  • Histidine
  • Analysis of Variance
  • Animals
  • Chlorpheniramine (pharmacology)
  • Disease Models, Animal
  • Emotions (drug effects)
  • Histamine H1 Antagonists (pharmacology)
  • Histidine (toxicity)
  • Male
  • Maze Learning (drug effects)
  • Memory Disorders (chemically induced)
  • Mice
  • Receptors, Histamine H1 (metabolism)

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