METHODS AND RESULTS: Seventy patients with a first anterior AMI were prospectively and consecutively enrolled. Patients with previous MI,
autoimmune disease,
collagen vascular disease and arterial or
venous thrombosis history were excluded from this study. At the time of hospitalization, key demographic and clinical characteristics were collected including age, gender,
ethanol intake and presence of traditional risk factors for
atherosclerosis (
hypertension, diabetes, smoking,
hyperlipidemia, positive family history). Patients were evaluated for echocardiographic data, blood chemistry and ACA. Two-dimensional and Doppler echocardiographic examinations were performed in all patients within the first week and at 14 days after MI. LV
thrombus was detected in 30 (42.8%) patients. ACA
IgM levels were significantly higher in the patient group with LV
thrombus than in the group without
thrombus (12.44 ±4.12 vs. 7.69 ± 4.25 mpl, p = 0,01). ACA
IgG levels were also found higher in the group with LV
thrombus (24.2 ± 7.5 vs.17.98 ± 6.45 gpl, p = 0.02). Multivariate analyses revealed
diabetes mellitus, higher WMSI, lower MDT and higher ACA
IgM and higher ACA
IgG levels as independent predictors of left ventricular
thrombus formation.
CONCLUSIONS: Our data demonstrate that beside the low ejection fraction, lower MDT and higher wall motion score index, modestly elevated ACA
IgM and ACA
IgG levels are associated with LV
thrombus formation in patients with anterior MI.