Abstract | BACKGROUND: MATERIAL AND METHODS: Two male veterinarians (50- and 44-year-old) attempted suicide by injecting T-61 in the precordial area for the first one, and by ingesting 50 mL for the second. Both received NAC (for 14 days in the first case and only for 20 h in the second). Urine was collected for the serial determination of DMF, N-methylformamide (NMF), and N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC). RESULTS: Both patients developed only mild signs of liver injury. The metabolite of DMF, NMF, appeared rapidly in the urine, while a further delay was necessary for AMCC excretion. The kinetics of elimination of DMF and DMF metabolites were slightly slower than those reported in exposed workers. CONCLUSIONS: While both patients had a favorable outcome, there is no clear evidence that NAC could directly influence NMF and AMCC excretion. Further investigations of NMF and AMCC excretion, with and without NAC, would be indicated.
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Authors | Philippe Hantson, Antoine Villa, Anne-Cécile Galloy, Sara Negri, Giulia Esabon, Fabien Lambiotte, Vincent Haufroid, Robert Garnier |
Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
Vol. 48
Issue 7
Pg. 725-9
(Aug 2010)
ISSN: 1556-9519 [Electronic] England |
PMID | 20849330
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Amides
- Drug Combinations
- Quaternary Ammonium Compounds
- Tetracaine
- T 61
- Dimethylformamide
- Acetylcysteine
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Topics |
- Acetylcysteine
(therapeutic use)
- Amides
(poisoning)
- Dimethylformamide
(metabolism)
- Drug Combinations
- Humans
- Male
- Middle Aged
- Quaternary Ammonium Compounds
(poisoning)
- Suicide
- Tetracaine
(poisoning)
- Veterinarians
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