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[The expression of CD95 and activated antigens in peripheral blood lymphocyte subsets in patients with hand foot and mouth disease (HFMD)].

AbstractOBJECTIVE:
To investigate the expression of CD95 and special marker for activation of peripheral blood lymphocytes in patients with hand foot and mouth disease (HFMD) and its significance.
METHODS:
Immunofluorescent two-color flow cytometry was used to study the expression of CD95 and HLA-DR on lymphocytes in 58 patients with HFMD and 34 normal controls.
RESULTS:
Expression of CD3+ T cells was significantly lower in patients (63.82 +/- 7.74)% than that in controls (P < 0.001), meanwhile the expression of CD4+ T cells was (34.29 +/- 7.33)%, significantly lower than that of the controls (P < 0.005). The percentage of lymphocytes expressing HLA-DR in patients was (23.77 +/- 5.78)%, significantly higher than that of the controls (P < 0.005). Significant difference was observed in the expression of HLA- DR on CD8+ T cells in patients (1.34 +/- 1.12)% as compared with controls (P < 0.005). No significant difference in the expression of CD95 on lymphocytes was observed between patients and the controls (P > 0.05).
CONCLUSION:
The findings support that cellular immunodeficiency exists in patients and that lymphocytes were abnormally activated in the patients. The activation of peripheral blood T lymphocytes in patients mainly involves CD8 subset and it may play an important role in the immune response to antiviral infection.
AuthorsMing-Li Zhu, Song-Ping Zhang, He-Qian Cao, Wei-Feng Liang, Jian-Hua Yu, Guo-Qiang Lou
JournalZhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 24 Issue 1 Pg. 33-5 (Feb 2010) ISSN: 1003-9279 [Print] China
PMID20848845 (Publication Type: Journal Article)
Chemical References
  • Antigens
  • fas Receptor
Topics
  • Antigens (genetics, immunology)
  • CD4-Positive T-Lymphocytes (immunology)
  • Case-Control Studies
  • Cells, Cultured
  • Child, Preschool
  • Hand, Foot and Mouth Disease (genetics, immunology)
  • Humans
  • Infant
  • Lymphocyte Count
  • Male
  • T-Lymphocyte Subsets (immunology)
  • fas Receptor (genetics, immunology)

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